If your cat is uncomfortable with you, they are more likely to struggle and try to escape when you hold them. Spend some time petting your cat and talking to them soothingly before you try to pick them up.
Why is it important to hold a Ragdoll cat properly?
Ragdoll cats are relatively large, so it is important to support their weight evenly when holding them. If you do not support their weight evenly, you could injure yourself.